N-Aryl Lactams by Regioselective Ozonation of N-Aryl Cyclic Amines
نویسندگان
چکیده
منابع مشابه
N-Aryl Lactams by Regioselective Ozonation of N-Aryl Cyclic Amines
Ozonation of N-aryl-cyclic amines in organic solvents gave N-aryl-lactams regioselectively. In particular, 4-(4-aminophenyl)-morpolin-3-one, a key intermediate in the preparation of factor Xa inhibitors, was obtained in fair yields. The method represents an alternative approach for the lactamization of tertiary N-arylic substrates and is based on a "metal-free" introduction of the carbonyl func...
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ژورنال
عنوان ژورنال: ISRN Organic Chemistry
سال: 2012
ISSN: 2090-5157
DOI: 10.5402/2012/281642